Review Article Open Access

Insulin-Like Growth Factor 1 Gene and Growth Traits Correlations in Sheep: A Systematic Review

Thabang Sako1, Thobela Lousi Tyasi1 and Jones Ng’ambi2
  • 1 Department of Agricultural Economics and Animal Production, School of Agricultural and Environmental Sciences, University of Limpopo, Private Bag X1106, Sovenga, 0727, Limpopo, South Africa
  • 2 Department of Agriculture and Animal Health, University of South Africa, Florida Science Campus, Private Bag X6, Florida 1710, South Africa

Abstract

Insulin-like Growth Factor 1 (IGF1) is a growth factor gene of the endocrine that is known for involvement in growth, as well as fetal development and metabolism. The IGF1 is majorly embedded in the animal growth processes and as a result, contributes to the improved output of meat and regulation of somatic cell growth with regards to the dietary conditions. There have been studies that investigated the effect of IGF1 on growth traits. However, as far as we know, there is no study that systematically reviewed the relationship between IGF1 and growth traits in sheep. Therefore, this systematic review aimed to systematically review the Single Nucleotide Polymorphisms (SNPs) of the IGF1 gene and their relationship with growth traits in sheep. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were used for identification, screening, eligibility and inclusion and 14 studies were found to be eligible. This systematic review used four search engines (PubMed, web of science, google scholar and science direct) and components of the research question identification of the Population, Exposure and Outcomes (PEO) to gather eligible studies. The results showed that 26 different SNPs were identified with no similar SNPs identified by the included articles. The results indicated that the identified SNPs (G855C, G857A, C271T and A91C) had a relationship with Birth Weight (BWt), Weaning Weight (WW), Body Weight (BW), Average Daily Gain (ADG), Body Length (BL), Withers Height (WH), Heart Girth (HG), Rump Length (RL), Rump Height (RH) and Paunch Girth (PG) in sheep. The IGF1 gene influences growth traits of sheep and as such G855C, G857A, C271T and A91C SNPs might be used as potentially viable genetic indicators for the betterment of performance traits in sheep during breeding programs. Further studies have to confirm the validity of the identified SNPs of the IGF1 gene.

References

Abousoliman, I., Reyer, H., Oster, M., Muráni, E., Mourad, M., Abdel-Salam Rashed, M., Mohamed, I., & Wimmers, K. (2020). Analysis of Candidate Genes for Growth and Milk Performance Traits in the Egyptian Barki Sheep. Animals, 10(2), 197. https://doi.org/10.3390/ani10020197
Al Qasimi, R., Hassan, A., & Khudair, B. Y. (2019). Effect of IGF-1 and GH Genes Polymorphism on Weights and Body Measurements of Awassi Lambs in Different Ages. Basrah Journal of Agricultural Sciences, 32(1), 39–46. https://doi.org/10.33762/bjas.2019.161201
Bayraktar, M., & Shoshin, O. M. (2021). Estimate of the Association of IGF-I and IGFALS Genes with Growth Traits in Hamdani Sheep. Brazilian Archives of Biology and Technology, 64(1), e21210262. https://doi.org/10.1590/1678-4324-2021210262
Bettany-Saltikov, J. (2010). Learning how to undertake a systematic review: Part 1. Nursing Standard, 24(50), 47–55. https://doi.org/10.7748/ns.24.50.47.s49
Ding, N., Tian, D., Li, X., Zhang, Z., Tian, F., Liu, S., Han, B., Liu, D., & Zhao, K. (2022). Genetic Polymorphisms of IGF1 and IGF1R Genes and Their Effects on Growth Traits in Hulun Buir Sheep. Genes, 13(4), 666. https://doi.org/10.3390/genes13040666
Esen, V. K., & Esen, S. (2023). Association of the IGF1 5′UTR Polymorphism in Meat-Type Sheep Breeds Considering Growth, Body Size, Slaughter, and Meat Quality Traits in Turkey. Veterinary Sciences, 10(4), 270. https://doi.org/10.3390/vetsci10040270
Kumar, S., Dahiya, S. P., Magotra, A., Ratwan, P., & Bangar, Y. (2023). Influence of single nucleotide polymorphism in the IGF-1 gene on performance and conformation traits in Munjal sheep. Zygote, 31(1), 70–77. https://doi.org/10.1017/s0967199422000545
Li, S., Zhou, H., Zhao, F., Fang, Q., Wang, J., Liu, X., Luo, Y., & Hickford, J. G. H. (2021). Nucleotide Sequence Variation in the Insulin-Like Growth Factor 1 Gene Affects Growth and Carcass Traits in New Zealand Romney Sheep. DNA and Cell Biology, 40(2), 265–271. https://doi.org/10.1089/dna.2020.6166
Machado, A. L., Meira, A. N., Jucá, A. de F., Azevedo, H. C., Muniz, E. N., Coutinho, L. L., Mourão, G. B., Pedrosa, V. B., & Pinto, L. F. B. (2021). Variants in GH, IGF1, and LEP genes associated with body traits in Santa Inês sheep. Scientia Agricola, 78(3), e20190216. https://doi.org/10.1590/1678-992x-2019-0216
Malewa, A. Dg., & Awaluddin. (2022). Polymorphisms of Palu Sheep IGF-1 Gene and Their Relationship with Skeletal Growth. Tropical Animal Science Journal, 45(1), 9–15. https://doi.org/10.5398/tasj.2022.45.1.9
Nazari, F., Noshary, A., & Hemati, B. (2016). Association between insulin-like growth factor I polymorphism and early growth traits in Iranian Zandi sheep, found Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP). Iranian Journal of Applied Animal Science, 6(3), 665–669.
Proskura, W. S., & Szewczuk, M. (2014). The polymorphism in the IGF1R gene is associated with body weight and average daily weight gain in Pomeranian Coarsewool ewes. Pakistan Veterinary Journal, 34(4), 514–517.
Raji, A. O., Mohammed, A., Igwebuike, J. U., & Alphonsus, C. (2017). Association of IGF 1 gene polymorphisms with some morphometric traits of Nigerian indigenous sheep breeds. Nigerian Journal of Biotechnology, 34, 97–104. https://doi.org/10.4314/njb.v34i1.13
Trukhachev, V., Skripkin, V., Kvochko, A., Kulichenko, A., Kovalev, D., Pisarenko, S., Volynkina, A., Selionova, M., Aybazov, M., Golovanova, N., Yatsyk, O., & Krivoruchko, A. (2016). Associations Between Newly Discovered Polymorphisms of the CEBPD GENE LOCUS and Body Parameters in Sheep. Animal Biotechnology, 27(4), 217–222. https://doi.org/10.1080/10495398.2016.1168304
Valencia, C. P. L., Franco, L. Á. Á., & Herrera, D. H. (2022). Association of single nucleotide polymorphisms in the CAPN, CAST, LEP, GH, and IGF-1 genes with growth parameters and ultrasound characteristics of the Longissimus dorsi muscle in Colombian hair sheep. Tropical Animal Health and Production, 54, 82. https://doi.org/10.1007/s11250-022-03086-x

American Journal of Animal and Veterinary Sciences
Volume 19 No. 2, 2024, 183-192

DOI: https://doi.org/10.3844/ajavsp.2024.183.192

Submitted On: 15 November 2023 Published On: 25 May 2024

How to Cite: Sako, T., Tyasi, T. L. & Ng’ambi, J. (2024). Insulin-Like Growth Factor 1 Gene and Growth Traits Correlations in Sheep: A Systematic Review. American Journal of Animal and Veterinary Sciences, 19(2), 183-192. https://doi.org/10.3844/ajavsp.2024.183.192

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Keywords

  • Body Measurements
  • Candidate Gene
  • Polymorphism
  • Sheep
  • Systemic Review