Research Article Open Access

Paracetamol: A Focus on Dogs

Charbel Fadel1, Irene Sartini1 and Mario Giorgi2
  • 1 University of Sassari, Italy
  • 2 University of Pisa, Italy


Paracetamol (APAP) is an aniline analgesic, antipyretic and non-narcotic. It is an essential drug, widely used in human medicine. In veterinary medicine it has an extra label use in many countries. It is used exclusively in some animals, including dogs. It has a mechanism of action similar to that of NSAIDs, as well as other unique characteristics. A variety of studies on APAP in dogs have been published since its introduction into several clinical practices, covering pharmacokinetics, pharmacodynamics, effectiveness and toxicity when inadvertent or accidental overdosing occurs. When taken at therapeutic doses, APAP has been proven to be a powerful and effective analgesic and antipyretic in dogs, as well as having some anti-inflammatory effects. On the other hand, it should be used with caution. This study is a documentation of the therapeutic, toxic and lethal doses of APAP in dogs, as well as the therapeutic effects, clinical application, mostly for the control of post-operative pain and its toxic effects.

American Journal of Animal and Veterinary Sciences
Volume 16 No. 4, 2021, 247-262


Submitted On: 14 July 2021 Published On: 2 November 2021

How to Cite: Fadel, C., Sartini, I. & Giorgi, M. (2021). Paracetamol: A Focus on Dogs. American Journal of Animal and Veterinary Sciences, 16(4), 247-262.

  • 13 Citations



  • Dogs
  • Paracetamol
  • Pharmacokinetics
  • Pharmacodynamics
  • Toxicity