Research Article Open Access

Anticonvulsant Activity of Hydroalcoholic Phoenix dactylifera Fruit Extract and Pimpinella anisum Oil in Mice

Sameh Mohamed Mostafa EL-Nabtity1, Ahmed Shaban Abdelaziz1, Manar Salah Moselhi1 and Mario Giorgi2
  • 1 Zagazig University, Egypt
  • 2 University of Pisa, Italy

Abstract

Epilepsy is a group of long-term neurological disorders characterized by epileptic seizures. The present study sought to investigate the anticonvulsant and neuroprotective Activity of Hydroalcoholic Phoenix dactylifera fruit extract (HAPD) and Pimpinella Anisum Oil (PAO) against Pentylenetetrazole (PTZ) and Maximal Electric Shock (MES) induced a seizure in mice. Mice groups were treated with HAPD1000 mg/kg, PAO 4 ml/kg. The onset of a seizure and generalized seizure were measured, followed by Gamma-Aminobutyric Acid (GABA) and antioxidant enzymes assessments. The potential of these substances to induce any neurological toxicity was also evaluated by using rotarod, forced swim test and horizontal screen test. The current study demonstrates that HAPD and PAO delay onset of the seizure and generalized seizure, also elevated GABA and antioxidant enzymes level and haven’t any neurological toxicity. The current study suggests that hydroalcoholic Phoenix dactylifera extract and Pimpinella anisum oil have anticonvulsant, neuroprotective and antioxidant activity and can increase brain GABA level.

American Journal of Animal and Veterinary Sciences
Volume 14 No. 2, 2019, 127-138

DOI: https://doi.org/10.3844/ajavsp.2019.127.138

Submitted On: 15 March 2019 Published On: 25 May 2019

How to Cite: EL-Nabtity, S. M. M., Abdelaziz, A. S., Moselhi, M. S. & Giorgi, M. (2019). Anticonvulsant Activity of Hydroalcoholic Phoenix dactylifera Fruit Extract and Pimpinella anisum Oil in Mice. American Journal of Animal and Veterinary Sciences, 14(2), 127-138. https://doi.org/10.3844/ajavsp.2019.127.138

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Keywords

  • Seizure
  • GABA
  • Pentylenetetrazole
  • Maximal Electric Shock
  • Phoenix dactylifera Fruit Extract
  • Pimpinella anisum oil