Review Article Open Access

RCMV ALL-03 Model and Study of CMV Pathogenesis in Congenital Infection

Ashwaq Ahmed Abdullah1, Krishnan Nair Balakrishnan1, Yusuf Abba1, Faez Firdaus Jesse Abdullah1, Zeenatul Allaudin Nazariah1, Rasedee Abdullah1, Noordin Mohamed Mustapha1 and Mohd-Azmi Mohd-Lila1
  • 1 Universiti Putra Malaysia, Malaysia

Abstract

Cytomegalovirus (CMV) is one of the most commonly studied members of the Herpesviridae family. So far several strains have been identified but human CMV (HCMV) remains the most important due to its ability to infect humans and also cross the placenta causing neonatal infection and mortality. However, there are several limitations in the study of this strain which includes availability and use of model animals. Although strains such as Rhesus CMV (RhCMV), Guinea pig CMV (GPCMV) and Rat CMV (RCMV ALL-03) have been shown to cross the placenta and exhibit similar pathogenesis to HCMV, only RCMV ALL-03 can be conveniently used without much limitations as guinea pigs are resistant to antiviral drugs, while rhesus monkeys are seropositive, considered costly and have ethical use restrictions. We therefore propose the use of RCMV ALL-03 as a model for the study of CMV infection.

American Journal of Animal and Veterinary Sciences
Volume 10 No. 3, 2015, 170-186

DOI: https://doi.org/10.3844/ajavsp.2015.170.186

Submitted On: 11 March 2015 Published On: 18 July 2015

How to Cite: Abdullah, A. A., Balakrishnan, K. N., Abba, Y., Jesse Abdullah, F. F., Nazariah, Z. A., Abdullah, R., Mustapha, N. M. & Mohd-Lila, M. (2015). RCMV ALL-03 Model and Study of CMV Pathogenesis in Congenital Infection. American Journal of Animal and Veterinary Sciences, 10(3), 170-186. https://doi.org/10.3844/ajavsp.2015.170.186

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Keywords

  • Cytomegalovirus
  • Animal Model
  • Congenital Infection
  • Sensory Neural Hearing Defect (SNHD)
  • Central Nervous System Abnormalitis