Research Article Open Access

Inefficacy of Topical Diclofenac in Arthritic Horses

Nicolás F. Villarino1, Tomas J. Vispo1, Marcos1, Ferrante1 and María F. Landoni1
  • 1 University of La Plata, Argentina

Abstract

The objective of the present study was test the anti-inflammatory efficacy of diclofenac dietilamine, applied epicutaneously at a dose rate of 0.44 mg kg-1, in a model of acute arthritis in horses. Four clinical end-points, as well as two biochemical markers, were used as surrogate markers of the required clinical response (analgesia, anti-inflammatory). Low diclofenac concentrations were measured in blood (Cmax 0.04±0.03 ug mL-1) and synovial fluid (Cmax 0.08 ±0.08 ug mL-1) from the first to the last sampling time. The statistical comparison of the clinical end-points and biochemical markers between placebo and dicilofenac treated group indicated a lack of pharmacological effect of this compound after epicutaneous administration.

American Journal of Animal and Veterinary Sciences
Volume 1 No. 1, 2006, 8-12

DOI: https://doi.org/10.3844/ajavsp.2006.8.12

Submitted On: 12 September 2006 Published On: 30 June 2006

How to Cite: Villarino, N. F., Vispo, T. J., Marcos, Ferrante, & Landoni, M. F. (2006). Inefficacy of Topical Diclofenac in Arthritic Horses. American Journal of Animal and Veterinary Sciences, 1(1), 8-12. https://doi.org/10.3844/ajavsp.2006.8.12

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Keywords

  • NSAIDs
  • horse
  • arthritis
  • diclofenac
  • transdermal