Inefficacy of Topical Diclofenac in Arthritic Horses
Nicolás F. Villarino, Tomas J. Vispo, Marcos, Ferrante and María F. Landoni
DOI : 10.3844/ajavsp.2006.8.12
American Journal of Animal and Veterinary Sciences
Volume 1, Issue 1
The objective of the present study was test the anti-inflammatory efficacy of diclofenac dietilamine, applied epicutaneously at a dose rate of 0.44 mg kg-1, in a model of acute arthritis in horses. Four clinical end-points, as well as two biochemical markers, were used as surrogate markers of the required clinical response (analgesia, anti-inflammatory). Low diclofenac concentrations were measured in blood (Cmax 0.04±0.03 ug mL-1) and synovial fluid (Cmax 0.08 ±0.08 ug mL-1) from the first to the last sampling time. The statistical comparison of the clinical end-points and biochemical markers between placebo and dicilofenac treated group indicated a lack of pharmacological effect of this compound after epicutaneous administration.
© 2006 Nicolás F. Villarino, Tomas J. Vispo, Marcos, Ferrante and María F. Landoni. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.