American Journal of Biochemistry and Biotechnology

Introduction to Structural and Functional Proteomics

One major problem still escaping a solution to humans is cancer that is being studied with some result at molecular scale as strongly interlinked to differentiation, ageing and proliferation, but also to ecology. Its solution requires more coordinated efforts worldwide at the basic level subtracting the lead to the corporations that have been so far quite ineffective in both side of the Ocean linked to hospital and health-related institutions and we will be able to solve it only approaching with quite more focus the molecular quantitative scale correlating for human race benefits all pending problems in medicine (ageing, differentiation, cancer metastasis) at the protein level. As Guest Editor I am here by providing in this Special Issue of American Journal of Biochemistry and Biotechnology six representative examples of these efforts from both the western and eastern parts of the world, namely six examples going:

  1. from molecular dynamics simulations of M2 protein in potential drugs discovery to an application to influenza virus
  2. from NAPPA QCM_D Nanoconductometric Assay to Drug-Protein Interactions for Clinical Research,
  3. from Raman Spectrocopy to Protein Crystal Nucleation and Growth
  4. from structural characterization at the atomic level of a molecular nano-machine to the state of the art of Helicobacter pylori flagellum organization
  5. from Synchrotron Powder Diffraction Study to the Radiation Damage with Langmuir Blodgett Nanotemplate Crystallised Protein
  6. from Site-directed Mutagenesis to probing the Substrate Specificity and Intersubunit Interactions of Brevundimonas diminuta Glutaryl Acylase

Research Article

Structural Characterization at the Atomic Level of a Molecular Nano-Machine: The State of the Art of Helicobacter Pylori Flagellum Organization

Ivana Pulić, Valentina Loconte and Giuseppe Zanotti

Pages : 143-161

DOI : 10.3844/ajbbsp.2014.143.161

Published On : November 12, 2014

Synchrotron Powder Diffraction Study of Radiation Damage in Langmuir Blodgett Nanotemplate Crystallised Protein

Jonathan P. Wright, Eugenia Pechkova and Claudio Nicolini

Pages : 162-168

DOI : 10.3844/ajbbsp.2014.162.168

Published On : November 12, 2014

Probing the Substrate Specificity and Intersubunit Interactions of Brevundimonas Diminuta Glutaryl Acylase with Site-Directed Mutagenesis

Michael Eldarov, Anna Lyashenko, Tatyana Sherbakova, Dmitry Suplatov, KirillKopylov and Vytas Svedas

Pages : 169-179

DOI : 10.3844/ajbbsp.2014.169.179

Published On : November 12, 2014

Docking and Molecular Dynamics Simulations in Potential Drugs Discovery: An Application to Influenza Virus M2 Protein

Marine E. Bozdaganyan, Philipp S. Orekhov, Nicola L. Bragazzi, Donatella Panatto, Daniela Amicizia, Eugenia Pechkova, Claudio Nicolini and Roberto Gasparini

Pages : 180-188

DOI : 10.3844/ajbbsp.2014.180.188

Published On : November 11, 2014

Drug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric Assay

Claudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi and Eugenia Pechkova

Pages : 189-201

DOI : 10.3844/ajbbsp.2014.189.201

Published On : November 17, 2014

Raman Spectroscopy of Protein Crystal Nucleation and Growth

Pechkova Eugenia, Maksimov, Georgy, Parshina Evgenia, Maksimov Evgenii, Kutusov Nikolai, Brazhe Nadezda, Tarasova Irina, Stefano Fiordoro and Nicolini Claudio

Pages : 202-207

DOI : 10.3844/ajbbsp.2014.202.207

Published On : December 8, 2014