Research Article Open Access

Evaluation of Anti-Inflammatory Potential of Turmimax® an in vivo and in vitro Study

Firoz Hussain H M.1, Nanjundaiah S.1, Sadashiva Channangihalli Thimmegowda1, Neethumol Benny1 and Rashmi Y.1
  • 1 Research and Development, Star Hi Herbs Pvt Ltd, Jigani, Bangalore, Karnataka, India

Abstract

The main objective of this study was to investigate the in vivo and in vitro anti-inflammatory effects of the Turmimax® bio-enhanced turmeric formulation. By comparing the relative fluorescence intensities of the interleukins IL-8 (Interleukin-8) and IL-12 (Interleukin-12) cytokines in stimulated murine Raw 264.7 macrophages, Turmimax® was evaluated for its anti-inflammatory in vitro efficacy. Turmimax® was administered orally in two doses, 100 and 200 mg/kg, to assess its in vivo anti-inflammatory potential in ear edema induced by croton oil in mice and paw edema induced by histamine in albino rats. Diclofenac sodium 10 mg/kg p.o. is the standard drug. The results demonstrated that Turmimax® significantly and dose-dependently decreased the production of the inflammatory mediator’s interleukin-8 and IL-12. According to the current investigation results, Turmimax® has shown strong anti-inflammatory effects.

American Journal of Biochemistry and Biotechnology
Volume 18 No. 4, 2022, 386-393

DOI: https://doi.org/10.3844/ajbbsp.2022.386.393

Submitted On: 26 August 2022 Published On: 24 November 2022

How to Cite: H M., F. H., S., N., Thimmegowda, S. C., Benny, N. & Y., R. (2022). Evaluation of Anti-Inflammatory Potential of Turmimax® an in vivo and in vitro Study. American Journal of Biochemistry and Biotechnology, 18(4), 386-393. https://doi.org/10.3844/ajbbsp.2022.386.393

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Keywords

  • Turmimax®
  • Raw 264.7 Cell Line
  • IL-8 and IL-12
  • Flow Cytometry and Anti-Inflammatory Activity