TY - JOUR AU - H M., Firoz Hussain AU - S., Nanjundaiah AU - Thimmegowda, Sadashiva Channangihalli AU - Benny, Neethumol AU - Y., Rashmi PY - 2022 TI - Evaluation of Anti-Inflammatory Potential of Turmimax® an in vivo and in vitro Study JF - American Journal of Biochemistry and Biotechnology VL - 18 IS - 4 DO - 10.3844/ajbbsp.2022.386.393 UR - https://thescipub.com/abstract/ajbbsp.2022.386.393 AB - The main objective of this study was to investigate the in vivo and in vitro anti-inflammatory effects of the Turmimax® bio-enhanced turmeric formulation. By comparing the relative fluorescence intensities of the interleukins IL-8 (Interleukin-8) and IL-12 (Interleukin-12) cytokines in stimulated murine Raw 264.7 macrophages, Turmimax® was evaluated for its anti-inflammatory in vitro efficacy. Turmimax® was administered orally in two doses, 100 and 200 mg/kg, to assess its in vivo anti-inflammatory potential in ear edema induced by croton oil in mice and paw edema induced by histamine in albino rats. Diclofenac sodium 10 mg/kg p.o. is the standard drug. The results demonstrated that Turmimax® significantly and dose-dependently decreased the production of the inflammatory mediator’s interleukin-8 and IL-12. According to the current investigation results, Turmimax® has shown strong anti-inflammatory effects.