American Journal of Biochemistry and Biotechnology

Nanocrystalline Powders of Alkaline-Earth Phosphates as Precursors for Bioceramics

Parhi Purnendu, A. Ramanan and Alok R. Ray

DOI : 10.3844/ajbbsp.2006.61.65

American Journal of Biochemistry and Biotechnology

Volume 2, Issue 2

Pages 61-65


Bone is a nanocomposite made of calcium phosphates and collagen. Collagen has a typical fibrous structure, with diameter ranging from 100 nm to 2 μm. It is suggested that calcium hydroxyapatite, Ca10(PO4)6(OH)2 in the size range 5-50 nm embedded in the collagen framework provides mechanical strength to bone. Among calcium phosphates, apatites are found to be the most suitable for bone regeneration due to its biocompatibility. A contemporary theme is to prepare nanocrystallites of alkaline-earth phosphates that can be employed as precursors for making novel bioceramics. In this paper, we present our attempts to prepare nano-sized particles of alkaline-earth hydroxyapatites, A10(PO4)6(OH)2 where A= Ca, Sr and Ba through a metathetical route. Our work involved the use of same reactants treated under different reaction conditions. While hydrothermal route yielded well-crystalline nanorods, microwave resulted in agglomerated hydroxyapatites and reverse micellear route gave low crystalline apatites with less agglomeration.


© 2006 Parhi Purnendu, A. Ramanan and Alok R. Ray. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.