Research Article Open Access

Apoptosis of human Breast Cancer Cells induced by Ethylacetate Extracts of Propolis

Syamsudin 1, Partomuan Simanjuntak1, Ratna Djamil1 and Wan Lelly Heffen2
  • 1 ,
  • 2 , Afganistan
American Journal of Biochemistry and Biotechnology
Volume 6 No. 2, 2010, 84-88

DOI: https://doi.org/10.3844/ajbbsp.2010.84.88

Submitted On: 3 May 2010
Published On: 30 June 2010

How to Cite: Syamsudin, Simanjuntak, P., Djamil, R. & Heffen, W. L. (2010). Apoptosis of human Breast Cancer Cells induced by Ethylacetate Extracts of Propolis. American Journal of Biochemistry and Biotechnology, 6(2), 84-88. https://doi.org/10.3844/ajbbsp.2010.84.88

Abstract

Problem statement: Propolis has been ethno medically claimed to possess a wide array of biological activities including anticancer activity. The purpose of this research was to verify the folklore claim. Approach: This study was performed in a human breast carcinoma cell, MCF-7. Extract of propolis from different solvent, ethylacetate and n-buthanol showed induced apoptotic cells was detected by flow cytometry. Results: The results demonstrated that ethylacetate extract of propolis can induce apoptosis in MCF-7 as large as 13.21% during the 24 h incubation. On the other hand, doxorubicin is able to induce apoptosis as large as 18.89% during the 24 h incubation. Conclusion: The extracts of propolis ethylacetate had cytotoxic activity and triggers apoptosis on MCF-7 cells.

Download

Keywords

  • Apoptosis
  • propolis
  • human breast cancer cell