TY  - JOUR
AU  - Syamsudin, 
AU  - Simanjuntak, Partomuan 
AU  - Djamil, Ratna 
AU  - Heffen, Wan Lelly 
PY  - 2010
TI  - Apoptosis of human Breast Cancer Cells induced by Ethylacetate Extracts of Propolis
JF  - American Journal of Biochemistry and Biotechnology
VL  - 6
IS  - 2
DO  - 10.3844/ajbbsp.2010.84.88
UR  - https://thescipub.com/abstract/ajbbsp.2010.84.88
AB  - Problem statement: Propolis has been ethno medically claimed to possess a wide array of biological activities including anticancer activity. The purpose of this research was to verify the folklore claim. Approach: This study was performed in a human breast carcinoma cell, MCF-7. Extract of propolis from different solvent, ethylacetate and n-buthanol showed induced apoptotic cells was detected by flow cytometry. Results: The results demonstrated that ethylacetate extract of propolis can induce apoptosis in MCF-7 as large as 13.21% during the 24 h incubation. On the other hand, doxorubicin is able to induce apoptosis as large as 18.89% during the 24 h incubation. Conclusion: The extracts of propolis ethylacetate had cytotoxic activity and triggers apoptosis on MCF-7 cells.