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Frequency: Quarterly
ISSN: 1608-4217 (Print)
ISSN: 2410-8561 (Online)
Review Article Open Access

Role of HDL in Atherogenesis: Cholesterol and Atheroprotection

Anastasia Vladimirovna Poznyak1, Vasily Nikolaevich Sukhorukov2, Victor Yurievich Glanz2, Mikhail Аlexandrovich Popov3, Elizaveta Mikhailovna Pleshko3, Irina Alexandrovna Starodubtseva4, Tatiana Ivanovna Kovyanova3 and Alexander Nikolaevich Orekhov2
  • 1 Institute for Atherosclerosis Research, Osennyaya, Moscow, Russia
  • 2 Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, Abrikosovsky Lane, Moscow, Russia
  • 3 Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia
  • 4 Department of Polyclinic Therapy, NN Burdenko Voronezh State Medical University, 10 Studencheskaya Street, 394036 Voronezh, Russia

Abstract

Atherosclerosis is a major global health burden, responsible for a significant proportion of cardiovascular morbidity and mortality worldwide. Its high prevalence and severe clinical consequences have made it a subject of extensive research. Despite considerable advances, the complexity of its pathogenesis continues to hinder the development of effective preventive strategies and therapeutic interventions. Current evidence implicates chronic inflammation, dysregulated lipid metabolism, cholesterol accumulation, and multiple atherogenic modifications of LDL particles as key drivers of atherogenesis. In contrast, lipids of the HDL class are widely recognized for their atheroprotective properties. In this review, we consolidate current data on the role of HDL in atherosclerosis, with particular focus on HDL-associated cholesterol (HDL-C) as a clinically and biologically relevant parameter.

OnLine Journal of Biological Sciences
Volume 26 No. 1, 2026, 001

DOI: https://doi.org/10.3844/ojbsci.2026.26.01.001

Submitted On: 30 November 2023 Published On: 3 April 2026

How to Cite: Poznyak, A. V., Sukhorukov, V. N., Glanz, V. Y., Popov, M. �., Pleshko, E. M., Starodubtseva, I. A., Kovyanova, T. I. & Orekhov, A. N. (2026). Role of HDL in Atherogenesis: Cholesterol and Atheroprotection. OnLine Journal of Biological Sciences, 26(1), 1-10. https://doi.org/10.3844/ojbsci.2026.26.01.001

Open AccessCopyright: © 2026 Anastasia Vladimirovna Poznyak, Vasily Nikolaevich Sukhorukov, Victor Yurievich Glanz, Mikhail Аlexandrovich Popov, Elizaveta Mikhailovna Pleshko, Irina Alexandrovna Starodubtseva, Tatiana Ivanovna Kovyanova and Alexander Nikolaevich Orekhov. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • Atherosclerosis
  • HDL Cholesterol
  • HDL-C
  • Atherogenesis
  • Atheroprotection
  • Lipid Metabolism
  • LDL Oxidation
  • Cardiovascular Disease
  • Reverse Cholesterol Transport
  • Dyslipidemia
  • Inflammation
  • Plaque Formation
  • Lipoprotein
  • Cholesterol Efflux