VLDL in Atherosclerosis: Variety of Mechanistic Implications
- 1 Institute for Atherosclerosis Research, Moscow, Russia, Russia
- 2 Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, Moscow, Russia
- 3 Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow, Russia
- 4 Vascular Surgery Department, A. V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia
Abstract
Very-Low-Density Lipoprotein (VLDL) particles play a pivotal role as precursors for Intermediate-Density Lipoprotein (IDL) and eventually transform into Low-Density Lipoprotein (LDL). These particles have been categorized based on size and particle charge. Various types of VLDL impact diverse physiological processes in the human body. The accumulation of VLDL, along with other triglyceride-rich lipoproteins, significantly contributes to the development of atherosclerotic lesions, plaque rupture, progression of liver disorders such as hepatitis and Non-Alcoholic Fatty Liver Disease (NAFLD) and other conditions including obesity, insulin resistance and coronary artery disease. This review delves into the potential of VLDL in averting atherosclerosis and seeks to identify its therapeutic applications. Special emphasis is placed on exploring the role of VLDL in atherosclerosis, understanding its atherogenic properties and utilizing VLDL as a predictive marker for pathological conditions. The study design focuses on examining the data on pathways through which VLDL could be leveraged as a therapeutic target and preventive measure against cardiovascular diseases.
DOI: https://doi.org/10.3844/ojbsci.2024.777.787
Copyright: © 2024 Anastasia Vladimirovna Poznyak, Victor Yurievich Glanz, Vasily Nikolaevich Sukhorukov, Alexandra Alexandrovna Melnichenko, Victoria Alexandrovna Khotina, Arthur Anatolievich Lee, Dmitry Felixovich Beloyartsev and Alexander Nikolaevich Orekhov. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- Lipids
- Atherosclerosis
- Cardiovascular Disease
- Lipid Metabolism
- VLDL