Atherosclerosis as Age-Related Disease: The Potential of Sirtuins Treatment
- 1 R&D Laboratory, Institute for Atherosclerosis Research, Moscow, Russia
- 2 Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, Moscow, Russia
- 3 Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, Moscow, Russia
- 4 Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russia
- 5 Department of Vascular Surgery, A. V. Vishnevsky National Medical Research Center of Surgery, 27 Bolshaya Serpukhovskaya Street, 117997 Moscow, Russia
Abstract
Atherosclerosis, a global health concern, has attracted researchers worldwide due to its severe consequences. The elderly are particularly susceptible to cardiovascular diseases and events, making them a high-risk group. Although gaps in our understanding of atherosclerosis pathogenesis persist, it is evident that oxidative stress, endothelial dysfunction, inflammation, mitochondrial dysfunction, and autophagy impairments are key components of its development. Remarkably, these features are also observed in the aging process, suggesting that atherosclerosis may be an aging-associated disease. However, causality relationships between aging, atherosclerosis, and associated mechanisms continue to be speculative. Additionally, the lack of effective therapeutic options for both atherosclerosis and aging poses a significant challenge. Sirtuins hold promise as potential agents in addressing this challenge. This review aims to consolidate evidence on the association between atherosclerosis and vascular aging through mitochondrial dysfunction and discusses the potential role of sirtuins as therapeutic options for atherosclerosis.
DOI: https://doi.org/10.3844/ojbsci.2024.503.514
Copyright: © 2024 Anastasia Vladimirovna Poznyak, Victor Yurievich Glanz, Vasily Nikolaevich Sukhorukov, Alexandra Alexandrovna Melnichenko, Elizaveta Mikhailovna Pleshko, Alexander Leonidovich Golovyuk and Alexander Nikolaevich Orekhov. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- Atherosclerosis
- Cardiovascular Disease
- Sirtuins
- Aging
- CVD