Review Article Open Access

Unveiling the Impact of Endogenous Sialidases on Human Non-Infectious Disease Pathogenesis

Raisa Sergeevna Surkova1, Anastasia Vladimirovna Poznyak1, Dmitry Alexandrovich Kashirskikh1, Vasily Nikolaevich Sukhorukov1, Alexandra Alexandrovna Melnichenko2 and Alexander Nikolaevich Orekhov1
  • 1 Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow, Russia
  • 2 Institute for Atherosclerosis Research, Osennyaya Moscow, Russia


In our review, we have compiled existing information regarding the role of endogenous sialidases (neuraminidases) in the initiation and development of various non-infectious processes in humans. Precisely, pathologies of the cardiovascular system, tumor formations, neurological and metabolic disorders, and hereditary diseases. Sialidases appeared to be widely involved in a variety of human pathologies. An increase or decrease in the enzymatic activity of sialidase can be a triggering factor in the pathogenesis of these disorders. This led us to the conclusion that enzymes of this family are essential for the normal functioning of human organisms. Therefore, with a detailed study of the characteristics and functions of sialidase, it is possible to develop new and effective diagnostic methods, treatment strategies, and prevention of many important human diseases. In this review, we are linking all sialidase-related features of different diseases, which can set a direction for further studies.

OnLine Journal of Biological Sciences
Volume 24 No. 3, 2024, 302-312


Submitted On: 18 September 2023 Published On: 10 February 2024

How to Cite: Surkova, R. S., Poznyak, A. V., Kashirskikh, D. A., Sukhorukov, V. N., Melnichenko, A. A. & Orekhov, A. N. (2024). Unveiling the Impact of Endogenous Sialidases on Human Non-Infectious Disease Pathogenesis. OnLine Journal of Biological Sciences, 24(3), 302-312.

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  • Sialidase
  • Neuraminidase
  • LDL
  • Cardiovascular Disease
  • Cancer