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Frequency: Quarterly
ISSN: 1608-4217 (Print)
ISSN: 2410-8561 (Online)
Research Article Open Access

Impact of B-Glucan Against Ehrlich Ascites Carcinoma Induced Renal Toxicity in Mice

Ahmed Flayyih Hasan1, Azhar Azher Alankooshi2,3, Alaa Saadi Abbood1, Ali Ghazi Dulimi4, Hiba Mohammed Al-Khuzaay5, Eslam Ahmed Elsaedy6 and Ehab Tousson3
  • 1 Department of Biology, Al-Farabi University College, Baghdad, Iraq
  • 2 Department of Human Physiology, Faculty of Medicine, Jabir Ibn Hayyan Medical University, Iraq
  • 3 Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt
  • 4 Department of Human Dentistry, Bilad Alrafidain University College, Diyala, Iraq
  • 5 Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
  • 6 Department of Biochemistry, Faculty of Medicine, Alexandria University, Tanta, Egypt

Abstract

Several studies have been focused on identifying alternative medicines for the treatment of cancer. This study aimed to investigate the impact of B-Glucans extract (BG) against Ehrlich Ascites Carcinoma (EAC) induced toxicity and tissue damage in kidney. A total of 40 mice were assigned randomly to four groups (G1, control; G2, B-Glucans (75 mg/kg bw/day) orally for 2 weeks; G3, EAC and G4, EAC + BG). Current results revealed, EAC induced significant elevation in urea, creatinine, potassium (k+), chloride (Cl-) ions, kidney injury and significant decrease in sodium (Na+) and calcium (Ca++) ions when compared to B-glucans and control groups. Conversely, EAC + B-glucans modulate these changes and improved the renal functions and structure. EAC induced renal dysfunction and B-Glucans has the ability to improve renal functions. We can conclude that; BG could be used as an adjuvant therapy for kidney in ascites of hepatocellular carcinoma, Schistosoma and hepatitis.

OnLine Journal of Biological Sciences
Volume 23 No. 1, 2023, 103-108

DOI: https://doi.org/10.3844/ojbsci.2023.103.108

Submitted On: 22 October 2022 Published On: 23 February 2023

How to Cite: Hasan, A. F., Alankooshi, A. A., Abbood, A. S., Dulimi, A. G., Mohammed Al-Khuzaay, H., Elsaedy, E. A. & Tousson, E. (2023). Impact of B-Glucan Against Ehrlich Ascites Carcinoma Induced Renal Toxicity in Mice. OnLine Journal of Biological Sciences, 23(1), 103-108. https://doi.org/10.3844/ojbsci.2023.103.108

Open AccessCopyright: © 2023 Ahmed Flayyih Hasan, Azhar Azher Alankooshi, Alaa Saadi Abbood, Ali Ghazi Dulimi, Hiba Mohammed Al-Khuzaay, Eslam Ahmed Elsaedy and Ehab Tousson. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • Ehrlich Ascites Carcinoma
  • B-Glucans
  • Kidney
  • Mice