Research Article Open Access

Impact of Vitamin B17 Against Growth of Colitis Bearing Mice Induced Variations in Colon Structure, AFP, CEA and PCNA Immunoreactivity

Gihan Hosny Abd Elsamie1, Sabah Gaber El-Banna1, Ehab Tousson2, Shatha Ghazi Felemban3 and Mohanad Salam Hussein1
  • 1 Institute of Graduate Studies and Research, Egypt
  • 2 Tanta University, Egypt
  • 3 Fakeeh College for Medical Science, Saudi Arabia

Abstract

Colitis alludes to inflammation of the internal coating of the colon that accompanied clinically through abdominal pains, diarrhea, weight loss, nausea. Current study aimed to study the impact of vitamin B17 against growth of colitis bearing mice induced variations in colon structure, AFP, CEA and PCNA immune reactivity. Forty female Swiss albino mice separated into 4 groups (Control, vitamin B17, colitis and post treated colitis with vitamin B17 groups). Our results revealed significant increase in serum AFP, CEA, colon injury and PCNA expressions. In contrast; post treated colitis with vitamin B17 improved the colon functions and structure, inhibit the proliferations, AFP and CEA. If established in human beings, these outcomes could recommend that; vitamin B17 can be utilized as an adjuvant treatment with chemotherapy drugs.

OnLine Journal of Biological Sciences
Volume 21 No. 3, 2021, 228-234

DOI: https://doi.org/10.3844/ojbsci.2021.228.234

Submitted On: 10 May 2021 Published On: 23 August 2021

How to Cite: Elsamie, G. H. A., El-Banna, S. G., Tousson, E., Felemban, S. G. & Hussein, M. S. (2021). Impact of Vitamin B17 Against Growth of Colitis Bearing Mice Induced Variations in Colon Structure, AFP, CEA and PCNA Immunoreactivity. OnLine Journal of Biological Sciences, 21(3), 228-234. https://doi.org/10.3844/ojbsci.2021.228.234

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Keywords

  • Colitis
  • Vitamin B17
  • Mice
  • Tumor Markers
  • PCNA Expressions