Research Article Open Access

Influence of Zein-Fucoidan Nanoparticles Loaded with Curcumin on the Maillard Reaction Between Casein and Lactose

Shiyang Li1, Yufan Liu1, Yuanda Song2, Zhengpeng Wei3, Falan Li1, Jinmei Wang3 and Shao Xuan Yu1
  • 1 College of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo 255049, Shandong, China
  • 2 School of Basic Medicine, Qilu Medical University, Zibo 255300, Shandong, China
  • 3 Rongcheng Taixiang Food Products Co., Ltd, Rongcheng 264309, Shandong, China

Abstract

The influence of curcumin-encapsulated Zein-Fucoidan Nanoparticles (CZFNPs) on the formation of Maillard reaction products (MRP) at the early, intermediate, and advanced stages in a casein-lactose (CN-Le) reaction system was systematically studied. As controls, the effects of Zein-Fucoidan Nanoparticles (ZFNPs) and free Curcumin (Cur) were also evaluated. The results showed that CZFNPs effectively inhibited the formation of fructosamine, Glyoxal (GO), as well as 3-deoxyglucosone (3-DG), markedly decreased the hydrolysis of CN, and consequently decreased the generation of fluorescent products and total Nε-(carboxymethyl) lysine (CML). Moreover, the inhibitory effects increased with the concentration of CZFNPs and heating time. In contrast, ZFNPs and Cur exhibited much weaker inhibitory effects on the formation of MRPs, particularly after 48 h of heating. Furthermore, CZFNPs reduced the 5-Hydroxymethylfurfural (5-HMF) content compared with Cur. Therefore, this work provides additional insights into the application of composite nanoparticles loaded with polyphenols in food.

American Journal of Biochemistry and Biotechnology
Volume 22 No. 2, 2026, 29-1

DOI: https://doi.org/10.3844/ajbbsp.2026.22.02.029

Submitted On: 3 September 2025 Published On: 30 July 2026

How to Cite: Li, S., Liu, Y., Song, Y., Wei, Z., Li, F., Wang, J. & Yu, S. X. (2026). Influence of Zein-Fucoidan Nanoparticles Loaded with Curcumin on the Maillard Reaction Between Casein and Lactose. American Journal of Biochemistry and Biotechnology, 22(2), 29-1. https://doi.org/10.3844/ajbbsp.2026.22.02.029

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Keywords

  • Zein-fucoidan Nanoparticles
  • Curcumin
  • Maillard Reaction
  • Casein
  • Lactose