Research Article Open Access

Ferulic Acid in Chinese Herbal Medicine: Regulating Autophagy for Oxidative Damage Reduction

Zhiyuan Lv1, Qiaozhen Zhao1, Shanbin Chen2,3, Heng Zhong2,3, Wenmei Zhao2, Wenmei Zhao3, Wenmei Zhao4, Ruiqi Luo2, Ruiqi Luo3, Wei Jiang2, Wei Jiang3, Wei Liu2, Wei Liu3, Xinglin Han2, Xinglin Han3, Mengchao He3, Mengchao He2, Xiaomeng Zhang3, Xiaomeng Zhang2, Deliang Wang3, Deliang Wang2, Mengmeng Zhang1 and Xinyu Xu1
  • 1 Department of Jinan Baotu Spring, Technology and Quality Winery Co, Ltd, Jinan, China
  • 2 Institute of Food and Fermentation Industries, National Research, Beijing, China
  • 3 International Joint Research Center for Liquor Quality and Safety, Beijing, China
  • 4 Chongzuo Key Laboratory of Biomedical Clinical Transformation, Guangxi, China


Ferulic Acid (FA) is the primary functional component in herbal plants and traditional fermented foods. To comprehend the mechanism of action of ferulic acid, in terms of its regulation of autophagy, antioxidants and the inhibition of inflammatory pathways, the study was conducted. Oxidatively damaged human-derived hepatocytes were treated with FA and the processing concentration of FA is from 50-800 μm. Autophagy, oxidative and inflammatory critical proteins were assessed through western blotting and qRTpcr with analysis of variance. The group treated with FA exhibited an increase in downstream Heme Oxygenase-1 (HO-1) and nuclear factor erythroid-2-related factor 2 (Nrf2) in the nucleus and a decrease in Kelch-like EC-associated protein 1 (Keap1) and Nrf2 in the cytosol, while inhibiting key inflammatory proteins, Cyclooxygenase-2 (COX-2) in comparison with oxidative stress group. Prior to this, autophagy-positive associated protein microtubule-associated protein 1 Light Chain 3 beta (LC3) were increased and protein sequels to some 1 (P62) were reduced. In summary, previous studies have only clarified that FA is a functional component, without clarifying its mechanism. FA as a precursor found in Chinese herbs and other phenols, demonstrates the capacity to reduce oxidative damage through autophagy, establishing an experimental foundation for the beneficial functions of Chinese herbal medicines and fermented products containing ferulic acid and providing a theoretical basis for future products

American Journal of Biochemistry and Biotechnology
Volume 20 No. 2, 2024, 132-139


Submitted On: 24 October 2023 Published On: 1 June 2024

How to Cite: Lv, Z., Zhao, Q., Chen, S., Zhong, H., Zhao, W., Luo, R., Jiang, W., Liu, W., Han, X., He, M., Zhang, X., Wang, D., Zhang, M. & Xu, X. (2024). Ferulic Acid in Chinese Herbal Medicine: Regulating Autophagy for Oxidative Damage Reduction. American Journal of Biochemistry and Biotechnology, 20(2), 132-139.

  • 0 Citations



  • Ferulic Acid
  • Human Hepayic Cell Line (LO2 Cells)
  • Autophagy
  • Inflammation
  • Oxidative Stress