Research Article Open Access

Vitamin D Supplements Tone Down the Progression of Atheromatous Plaque Formation in a Dose-Dependent Manner

Ahmed Farouk1, Khalid M. Mohany2, Magdy Algowhary3, Lobna A. Abdelzaher4, Heba E. M. El-Deek5, Ghada Hosny5 and Tahia Hashim Saleem2
  • 1 Cardiothoracic Surgery, Faculty of Medicine, Assiut University, Egypt
  • 2 Department of Biochemistry, Faculty of Medicine, Assiut University, Egypt
  • 3 Department of Cardiology, Faculty of Medicine, Assiut University, Egypt
  • 4 Department of Pharmacology, Faculty of Medicine, Assiut University, Egypt
  • 5 Department of Pathology, Faculty of Medicine, Assiut University, Egypt

Abstract

Hypovitaminosis D has a negative impact on the cardiovascular system. We performed the current study to investigate the expression of Vitamin D Receptor (VDR) in atherosclerotic human male aortas and to examine the effect of different doses of Vit. D supplementation on VDR expression in the aortas of male rats fed a High-Fat Diet (HFD). Human participants included 50 atherosclerotic male patients with anterior myocardial infarction and 131 control healthy males. Fifty male Wistar rats were divided into 2 groups: Control (Cont.) group; n = 10 and HFD fed rats; n = 40. The latter was divided equally into 4 subgroups according to the dose of Vit. D supplemented. Vitamin D was supplemented in 3 doses: (0.025, 0.05, 0.075 µg/kg) for a duration of 17 weeks. VDR expression score was immunohistochemically evaluated in aortas of both human and animal study groups. The current study revealed that Vit. D levels were significantly lower in atherosclerotic patients with myocardial infarctions compared to the human control group. Concurrent administration of Vit. D suppresses the progress of atheromatous plaque in rats feed a HFD in a dose-dependent manner. Consequently, it could be concluded that Vit. D supplements are recommended as a prophylaxis in patients at high risk of coronary artery disease.

American Journal of Biochemistry and Biotechnology
Volume 17 No. 3, 2021, 353-360

DOI: https://doi.org/10.3844/ajbbsp.2021.353.360

Submitted On: 20 May 2021 Published On: 5 October 2021

How to Cite: Farouk, A., Mohany, K. M., Algowhary, M., Abdelzaher, L. A., El-Deek, H. E. M., Hosny, G. & Saleem, T. H. (2021). Vitamin D Supplements Tone Down the Progression of Atheromatous Plaque Formation in a Dose-Dependent Manner. American Journal of Biochemistry and Biotechnology, 17(3), 353-360. https://doi.org/10.3844/ajbbsp.2021.353.360

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Keywords

  • Vitamin D
  • Vitamin D Receptors
  • Atherosclerosis