Vitamin D Supplements Tone Down the Progression of Atheromatous Plaque Formation in a Dose-Dependent Manner
- 1 Cardiothoracic Surgery, Faculty of Medicine, Assiut University, Egypt
- 2 Department of Biochemistry, Faculty of Medicine, Assiut University, Egypt
- 3 Department of Cardiology, Faculty of Medicine, Assiut University, Egypt
- 4 Department of Pharmacology, Faculty of Medicine, Assiut University, Egypt
- 5 Department of Pathology, Faculty of Medicine, Assiut University, Egypt
Abstract
Hypovitaminosis D has a negative impact on the cardiovascular system. We performed the current study to investigate the expression of Vitamin D Receptor (VDR) in atherosclerotic human male aortas and to examine the effect of different doses of Vit. D supplementation on VDR expression in the aortas of male rats fed a High-Fat Diet (HFD). Human participants included 50 atherosclerotic male patients with anterior myocardial infarction and 131 control healthy males. Fifty male Wistar rats were divided into 2 groups: Control (Cont.) group; n = 10 and HFD fed rats; n = 40. The latter was divided equally into 4 subgroups according to the dose of Vit. D supplemented. Vitamin D was supplemented in 3 doses: (0.025, 0.05, 0.075 µg/kg) for a duration of 17 weeks. VDR expression score was immunohistochemically evaluated in aortas of both human and animal study groups. The current study revealed that Vit. D levels were significantly lower in atherosclerotic patients with myocardial infarctions compared to the human control group. Concurrent administration of Vit. D suppresses the progress of atheromatous plaque in rats feed a HFD in a dose-dependent manner. Consequently, it could be concluded that Vit. D supplements are recommended as a prophylaxis in patients at high risk of coronary artery disease.
DOI: https://doi.org/10.3844/ajbbsp.2021.353.360
Copyright: © 2021 Ahmed Farouk, Khalid M. Mohany, Magdy Algowhary, Lobna A. Abdelzaher, Heba E. M. El-Deek, Ghada Hosny and Tahia Hashim Saleem. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- Vitamin D
- Vitamin D Receptors
- Atherosclerosis