Research Article Open Access

Weight Gain, Conditioning and Metabolic Syndrome: A Sled Dog Model

Aline Collin1, Shannon Jimmie1, Arleigh Reynolds1, Theresia Schnurr1, Lawrence Duffy1 and Kriya Dunlap1
  • 1 University of Alaska, United States


Type II Diabetes (T2D) and insulin resistance are growing national health concerns. Obesity is a risk factor for developing T2D and is associated with chronic and systemic inflammation. Exercise on the other hand has been shown to improve glucose metabolism and insulin sensitivity. We investigated the effects of conditioning and weight gain on adiponectin, tumor necrosis factor and glycosylated hemoglobin, three biomarkers of T2D. We measured the levels of these three biomarkers in racing, sedentary and overweight sled dogs. Exercise did not have a significant impact on the levels of the biomarkers, whereas weight gain had a negative effect. Using a sled dog model, we conclude that weight management is important to reduce the risk of T2D and its consequences.

American Journal of Biochemistry and Biotechnology
Volume 15 No. 3, 2019, 157-162


Submitted On: 13 May 2019 Published On: 18 August 2019

How to Cite: Collin, A., Jimmie, S., Reynolds, A., Schnurr, T., Duffy, L. & Dunlap, K. (2019). Weight Gain, Conditioning and Metabolic Syndrome: A Sled Dog Model. American Journal of Biochemistry and Biotechnology, 15(3), 157-162.

  • 1 Citations



  • Adiponectin
  • Sled Dogs
  • TNF
  • Type II Diabetes
  • Weight Gain