Research Article Open Access

Antimicrobial Effects of 1-Monocaprylin and 1-Monocaproin Through in vitro Growth Inhibition and Molecular Docking Studies

Palaniappan Maheswari1 and Kasthuri Revathi2
  • 1 Sathyabama University, India
  • 2 Ethiraj College for Women, India

Abstract

1-monocaproin and 1-monocaprylin synthesized through a novel process by the chemical reaction of glycidol and their respective fatty acids with copper acetate as the catalyst possessed the amphiphilic property. 1- monoacyl glycerols synthesized were found to exhibit antibacterial, antifungal, anti parasitic and antiviral properties. 1-monocaproin and 1-monocaprylin were able to show their antibacterial effect by inhibiting the growth of the Gram negative bacteria Escherichia coli, Pseudomonas aeruginosa and Gram positive bacteria Staphylococcus aureus, Bacillus subtilis at concentrations of 100–500 ppm. The Minimal Inhibitory Concentration (MIC) of both 1-monoacyl glycerols were found to be 0.5 ppm. 1-monocaproin and 1-monocaprylin were able to show their antifungal effect by inhibiting the growth of the filamentous fungi Mucor racemosus and Rhizopus stolonifer at the concentration of 1000 ppm. Based on the molecular interaction and common binding interaction study, 1-monocaproin is expected to exhibit a similar antiviral activity as that of Oseltamivir to H5N1 influenza virus hemagglutinin. 1-monocaprylin and 1-monocaproin synthesized using copper acetate could exhibit a broad spectrum antimicrobial effect in combination with other monoacyl glycerols or with other antimicrobial agents.

American Journal of Biochemistry and Biotechnology
Volume 13 No. 3, 2017, 123-131

DOI: https://doi.org/10.3844/ajbbsp.2017.123.131

Submitted On: 16 June 2017 Published On: 19 August 2017

How to Cite: Maheswari, P. & Revathi, K. (2017). Antimicrobial Effects of 1-Monocaprylin and 1-Monocaproin Through in vitro Growth Inhibition and Molecular Docking Studies. American Journal of Biochemistry and Biotechnology, 13(3), 123-131. https://doi.org/10.3844/ajbbsp.2017.123.131

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Keywords

  • Monoacyl Glycerols
  • 1-Monocaprylin
  • 1-Monocaproin
  • Antimicrobial
  • Anti Bacterial
  • Antifungal
  • Antiviral