Review Article Open Access

Review of the Progress in Corneal Neovascularization Animal Models

Shuci Tian1, Shurong Wang1, Yuxi He2, Xin Liu1, Ying Li1, Guanfang Su1 and Yan Zhang1
  • 1 The Second Hospital of JiLin University, China
  • 2 Norman Bethune Health Science Center of JiLin University, China


Corneal Neovascularization (CNV), the extensive growth of blood vessels from conjunctiva into the cornea. It is a sight-threatening condition that can decreases eyesight and even leads to blindness. The pathologic growth of blood vessels impairs light transmission, promotes scar formation and causes inflammations, which harm visual acuity. Abnormal angiogenesis plays an important role in the process of CNV, which may result from corneal wound healing. Neovascular eye disease is one of the most common eye diseases in clinical admissions. CNV blinds approximately 7 million people worldwide. Continued mechanistic studies are a key to the prevention and treatment of CNV. Research in CNV animal models is essential in eye diseases. Several main methods of CNV models preparation are summarized in this review.

American Journal of Biochemistry and Biotechnology
Volume 11 No. 4, 2015, 221-227


Submitted On: 21 May 2015 Published On: 28 November 2015

How to Cite: Tian, S., Wang, S., He, Y., Liu, X., Li, Y., Su, G. & Zhang, Y. (2015). Review of the Progress in Corneal Neovascularization Animal Models. American Journal of Biochemistry and Biotechnology, 11(4), 221-227.

  • 9 Citations



  • Corneal
  • Vascularization
  • Model
  • Preparation