Research Article Open Access

CD2 Shown to Facilitate CD4+ Cell Differentiation during Visceral Leishmaniasis, a Receptor Based Study

Sukrat Sinha1, Shanthy Sundaram2, Sanjiva Bimal1, Shubhankar Kumar Singh1 and Pradeep Das1
  • 1 Rajendra Memorial Research Institute of Medical Sciences (ICMR), India
  • 2 University of Allahabad, India

Abstract

This study addressed the role of CD2 on CD4+ T helper cells in relation to the TCRVα1 and CD70 in two groups of BALB/c mice viz control and infected (1×107 L. donovani promastigotes). The results showed with the downregulation of CD2 expression there is a pronounced decrease of TCRVα1 and CD70 on CD4+ cells in mice. An insight into the behavior of the cytokines viz IL-2, IFN-γ and TNF-α also showed disturbance in the concurrent efficiency of these cells in responding to the Leishmania donovoni infection. Hence it can be interpreted that probably CD2 plays an important role during maturation steps of CD4+ T cell differentiation during VL infection.

American Journal of Biochemistry and Biotechnology
Volume 11 No. 4, 2015, 214-220

DOI: https://doi.org/10.3844/ajbbsp.2015.214.220

Submitted On: 22 May 2015 Published On: 28 November 2015

How to Cite: Sinha, S., Sundaram, S., Bimal, S., Singh, S. K. & Das, P. (2015). CD2 Shown to Facilitate CD4+ Cell Differentiation during Visceral Leishmaniasis, a Receptor Based Study. American Journal of Biochemistry and Biotechnology, 11(4), 214-220. https://doi.org/10.3844/ajbbsp.2015.214.220

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Keywords

  • Visceral Leishmaniasis (VL)
  • T Cell Receptor Vα11(TCR V α11)
  • Peripheral Blood Mononuclear Cells (PBMNCs)
  • Cluster of Differentiation (CD70, CD2, CD4)