Research Article Open Access

Mesenchymal Stem Cell Transplantation for Retinal Degenerations and Dystrophies: Present and Future

Emma Ghazaryan1, Shurong Wang1, Yan Zhang1, Yuxi He1 and Guanfang Su1
  • 1 Jilin University, China

Abstract

Retinal degenerations are the main causes of irreversible blindness in developed countries. Up to date the main pathological mechanisms of these diseases are not fully understood and consequently there is no complete treatment option for those diseases. In this aspect stem cells have drawn attention of many researchers and health care professionals. Considering ethical issues, safety and facile isolation Mesenchymal Stem Cells (MSCs) are more preferable for practical use. They have been used for several preclinical and clinical trials. In general the results were promising, however broader practical use should be preceded by resolving many problems and questions. In this review we will describe mesenchymal stem cells, especially those derived from Bone-Marrow (BMSC), their main features, privilege, mechanisms of action and their potential use for the treatment of retinal degenerations. We will also discuss the results of several pre-clinical and clinical trials.

American Journal of Biochemistry and Biotechnology
Volume 10 No. 4, 2014, 241-250

DOI: https://doi.org/10.3844/ajbbsp.2014.241.250

Submitted On: 16 August 2014 Published On: 28 November 2014

How to Cite: Ghazaryan, E., Wang, S., Zhang, Y., He, Y. & Su, G. (2014). Mesenchymal Stem Cell Transplantation for Retinal Degenerations and Dystrophies: Present and Future. American Journal of Biochemistry and Biotechnology, 10(4), 241-250. https://doi.org/10.3844/ajbbsp.2014.241.250

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Keywords

  • Retinal Degenerations
  • Stem Cell
  • Mesenchymal Stem Cells
  • Transplantation
  • Preclinical and Clinical Trials