Research Article Open Access

Anti β2-Glycoprotein I Antibodies in Women with Recurrent Spontaneous Abortion

Abdolreza Sotoodeh Jahromi1, Mohammad Reza Farjam1, Farideh Mogharrab1, Ali Daryanavard2, Abdolhossien Madani2, Mahmoud Hossienpour2, Gita Manshoori3, Hossien Davoudi2, Mohammad Sadegh Gholvardi Yazdi2, Hossein Montazerghaem2 and Reza Safari Hassanlangi2
  • 1 Jahrom University of Medical Sciences, Iran
  • 2 Hormozgan University of Medical Sciences, Iran
  • 3 Tehran University of Medical Sciences, Iran


Problem statement: Antiphospholipid antibodies (aPL) are associated with repeated miscarriages and pregnancy complications, however their pathogenic mechanisms are still matter of research. Anti-β2 glycoprotein 1 (β2GPI) antibody is one of these aPL that its contribution to RSA risk remains poorly understood. There were not any data about role this auto-antibody in RSA in South of Iran. This study was conducted to assess Anti- β2GPI IgM and IgG as RSA risk factors for RSA in this area of Iran. Approach: This case-control study was carried out in gynecology special hospital of Hormozgan University of medical sciences, during 2004-2005. A number of 250 women with >3 consecutive idiopathic pregnancy losses as a case group and 200 age matched women with normal full term delivery and negative history of miscarriage as a controls were studied. All obtained sera from the case and the control groups were tested using an Enzyme Linked Immunosorbent Assay (ELISA) method for detection of anti-β2GPI IgM and IgG. Data was analyzed, using SAS 8 statistical software (chi square and t-test). Results: There were significant differences between the prevalence of positive anti-β2GPI IgM (p = 0.01) and IgG (p = 0.02) in the case group and the control group. A positive significant relationship was observed in the case group between number of abortion and seropositivity for anti-β2GPI IgG (p = 0.028, r = +0.181) and anti-β2GPI IgM (p = 0.0381, r = +0.014). Conclusion: This study showed anti-β2GPI antibodies are important causative agent for RSA in this area of Iran.

American Journal of Biochemistry and Biotechnology
Volume 6 No. 4, 2010, 264-267


Submitted On: 30 October 2010 Published On: 31 December 2010

How to Cite: Jahromi, A. S., Farjam, M. R., Mogharrab, F., Daryanavard, A., Madani, A., Hossienpour, M., Manshoori, G., Davoudi, H., Yazdi, M. S. G., Montazerghaem, H. & Hassanlangi, R. S. (2010). Anti β2-Glycoprotein I Antibodies in Women with Recurrent Spontaneous Abortion. American Journal of Biochemistry and Biotechnology, 6(4), 264-267.

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  • Anti-β2 Glycoprotein-I (β2GPI) antibody
  • recurrent spontaneous abortion
  • etiologic factor
  • Enzyme Linked Immunosorbent Assay (ELISA)
  • full-term delivery
  • antiphospholipid antibodies (aPL)
  • thrombosis