Research Article Open Access

Serotonergic Properties of the Roots of Clerodendron capitatum

Siddig Ibrahim Abdel Wahab1, Abdel Wahab Hassan Mohamed2, Osama Yousif Mohamed3, Manal Mohamed Elhassan Taha3, Ahmad Bustamam Abdul3 and Adel Sharaf Al-Zubairi3
  • 1 University Putra Malaysia, Malaysia
  • 2 Medicinal and Aromatic Plants Institute, Malaysia
  • 3 University of Khartoum, Sudan

Abstract

The aim of this study is to investigate the pharmacological effects of the methanolic extract of Clerodendron capitatum, CC, (family verbenaceae). These investigations were carried out on isolated frog rectus abdominus muscle and rabbit aortic strips and jejunum and non-pregnant rat uterus pretreated with oestradiol. Results showed that CC did not demonstrate any contracting, relaxant or blocking effects on frog rectus abdominus muscle and rat aortic strip preparations. The extract produced a concentration-dependent (p<0.05, t-test, n = 6) decrease of the normal rhythmic contraction of rabbit jejunum, however, this effect was reversed by prior addition of cyproheptadine (non-specific 5-HT antagonist). In addition, CC also produced a stimulant activity on rat uterus which was blocked by cyproheptadine. Future study is recommended to study the specificity of CC to different 5-HT receptors by using different isolated animal tissues and specific 5-HT antagonists.

American Journal of Biochemistry and Biotechnology
Volume 4 No. 4, 2008, 425-430

DOI: https://doi.org/10.3844/ajbbsp.2008.425.430

Submitted On: 22 October 2008 Published On: 31 December 2008

How to Cite: Wahab, S. I. A., Mohamed, A. W. H., Mohamed, O. Y., Taha, M. M. E., Abdul, A. B. & Al-Zubairi, A. S. (2008). Serotonergic Properties of the Roots of Clerodendron capitatum. American Journal of Biochemistry and Biotechnology, 4(4), 425-430. https://doi.org/10.3844/ajbbsp.2008.425.430

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Keywords

  • Clerodendrum capitatum
  • adrenergic
  • cholinergic effects
  • 5-HT