OnLine Journal of Biological Sciences

Clinical Uses and Molecular Aspects of Ozone Therapy: A Review

Ana Paula Pivotto, Fernanda Weyand Banhuk, Izabela Virginia Staffen, Maiara Aline Daga, Thaís Soprani Ayala and Rafael Andrade Menolli

DOI : 10.3844/ojbsci.2020.37.49

OnLine Journal of Biological Sciences

Volume 20, Issue 1

Pages 37-49

Abstract

Ozone was discovered over a hundred years ago and since then, it has been widely used in many areas, with the primary use as a disinfectant in various ways, but with applications in diverse conditions. More recently, the use of ozone has extended to other fronts, using it to treat different pathologies. Extensive studies have shown its effects, as well as the safety of its application in various modalities of use. Other studies showed its toxicity, which depends on the doses of use. Emerging evidence revealed that ozone also plays an important role in the wound healing and modulation of immune cells, describing the molecular pathways responsible for these actions and describing therapeutic actions in the treatment of wounds, pain, postoperative and infectious diseases. Ozone use has already been documented in different doses, forms of use and routes of application, depending on the clinical situation and an adaptation is necessary for a better result. Thus, this review summarizes the main clinical uses of ozone, presenting the molecular pathways responsible for its actions, as well as discussing the main routes of use, doses and, vehicles used in the clinic.

Copyright

© 2020 Ana Paula Pivotto, Fernanda Weyand Banhuk, Izabela Virginia Staffen, Maiara Aline Daga, Thaís Soprani Ayala and Rafael Andrade Menolli. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.