OnLine Journal of Biological Sciences

Hypermethylation and Hypomethylation of DNA: Implication for Diagnosis and Prognosis of Prostate Cancer

Lubos Danisovic and Stanislav Ziaran

DOI : 10.3844/ojbsci.2015.83.88

OnLine Journal of Biological Sciences

Volume 15, Issue 2

Pages 83-88


Prostate cancer belongs to the most common cancers and it is the second leading cause of cancer death in men. A genetic predisposition with epigenetic changes in DNA contributes to the development of the disease. DNA hypermethylation and hypomethylation belong to the most studied epigenetic changes in prostate cancer development. Both forms may lead to chromosomal instability and transcriptional gene silencing. This article is aimed at brief review of information in respect to DNA hypermethylation and hypomethylation in the prostate cancer development. Moreover, we discuss their implication for diagnosis and prognosis of prostate cancer.


© 2015 Lubos Danisovic and Stanislav Ziaran. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.