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Frequency: Quarterly
ISSN: 1608-4217 (Print)
ISSN: 2410-8561 (Online)
Review Article Open Access

Hypermethylation and Hypomethylation of DNA: Implication for Diagnosis and Prognosis of Prostate Cancer

Lubos Danisovic1 and Stanislav Ziaran2
  • 1 University of the Comenius, Slovakia
  • 2 Comenius University, Slovakia

Abstract

Prostate cancer belongs to the most common cancers and it is the second leading cause of cancer death in men. A genetic predisposition with epigenetic changes in DNA contributes to the development of the disease. DNA hypermethylation and hypomethylation belong to the most studied epigenetic changes in prostate cancer development. Both forms may lead to chromosomal instability and transcriptional gene silencing. This article is aimed at brief review of information in respect to DNA hypermethylation and hypomethylation in the prostate cancer development. Moreover, we discuss their implication for diagnosis and prognosis of prostate cancer.

OnLine Journal of Biological Sciences
Volume 15 No. 2, 2015, 83-88

DOI: https://doi.org/10.3844/ojbsci.2015.83.88

Submitted On: 3 January 2015 Published On: 13 June 2015

How to Cite: Danisovic, L. & Ziaran, S. (2015). Hypermethylation and Hypomethylation of DNA: Implication for Diagnosis and Prognosis of Prostate Cancer. OnLine Journal of Biological Sciences, 15(2), 83-88. https://doi.org/10.3844/ojbsci.2015.83.88

Open AccessCopyright: © 2015 Lubos Danisovic and Stanislav Ziaran. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • Prostate Cancer
  • DNA Hypermethylation
  • DNA Hypomethylation
  • Diagnosis
  • Prognosis