Neuroscience International

The Glia Connection of the Glutamate/Glutamine Shuttle

Angelina Rodriguez and Arturo Ortega

DOI : 10.3844/amjnsp.2012.32.38

Neuroscience International

Volume 3, Issue 1

Pages 32-38


Problem statement: Glia cells outnumber neurons but their role in synaptic transmission is still matter of debate. The recycling of Glutamate, the main excitatory neurotransmitter, carried out by the glutamate/glutamine shuttle, requires the involvement of glia, suggesting their involvement in neurotransmission. Approach: This review focuses on novel functions of glia proteins involved in this cycle. Results: An activity-dependent interaction of glial glutamate transporters, the Na+/K+ ATPase, the glutamine and glucose transporters might support glutamatergic neurotransmission. Conclusion: Glia cells that surround glutamatergic contacts, respond to synaptic activity and modify accordingly, the amount and function of the proteins involved in their interaction with neurons thus assuring a synaptic transmission.


© 2012 Angelina Rodriguez and Arturo Ortega. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.