Nutritional control of HIV-AIDS-A case for Selenium
Parisa Kalantari, Hema Vunta, Umamaheswari D. Palempalli, C. Channa Reddy, Andrew J. Henderson and K. Sandeep Prabhu
DOI : 10.3844/ajidsp.2007.195.201
American Journal of Infectious Diseases
Volume 3, Issue 4
Selenium (Se) is a micronutrient that is incorporated into proteins. Some of the selenoenzymes such as GPXs and thioredoxin reductases exhibit glutathione peroxidase-dependent activities towards organic and inorganic peroxides. Thus, selenoenzymes play a pivotal role in mitigating oxidative stress caused by accumulation of peroxides. In this respect, selenoproteins may interfere with the transcription-driven by oxidative stress-dependent signaling mechanisms to influence the expression of redox sensitive genes, including inflammatory cytokines and HIV provirus. Several epidemiological studies support our view that Se supplementation affects transcription of HIV; however, the underlying mechanism is not elucidated. In this mini review, we consider the relationship between Se and HIV and propose possible mechanisms by which Se controls HIV transcription.
© 2007 Parisa Kalantari, Hema Vunta, Umamaheswari D. Palempalli, C. Channa Reddy, Andrew J. Henderson and K. Sandeep Prabhu. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.