TY  - JOUR
AU  - Kalantari, Parisa 
AU  - Vunta, Hema 
AU  - Palempalli, Umamaheswari D. 
AU  - Reddy, C. Channa 
AU  - Henderson, Andrew J. 
AU  - Prabhu, K. Sandeep 
PY  - 2007
TI  - Nutritional control of HIV-AIDS-A case for Selenium
JF  - American Journal of Infectious Diseases
VL  - 3
IS  - 4
DO  - 10.3844/ajidsp.2007.195.201
UR  - https://thescipub.com/abstract/ajidsp.2007.195.201
AB  - Selenium (Se) is a micronutrient that is incorporated into proteins. Some of the selenoenzymes such as GPXs and thioredoxin reductases exhibit glutathione peroxidase-dependent activities towards organic and inorganic peroxides. Thus, selenoenzymes play a pivotal role in mitigating oxidative stress caused by accumulation of peroxides. In this respect, selenoproteins may interfere with the transcription-driven by oxidative stress-dependent signaling mechanisms to influence the expression of redox sensitive genes, including inflammatory cytokines and HIV provirus. Several epidemiological studies support our view that Se supplementation affects transcription of HIV; however, the underlying mechanism is not elucidated. In this mini review, we consider the relationship between Se and HIV and propose possible mechanisms by which Se controls HIV transcription.