American Journal of Biochemistry and Biotechnology

Soft Sensor Modeling of Product Concentration in Glutamate Fermentation using Gaussian Process Regression

Rongjian Zheng and Feng Pan

DOI : 10.3844/ajbbsp.2016.179.187

American Journal of Biochemistry and Biotechnology

Volume 12, Issue 3

Pages 179-187


The on-line control of glutamate fermentation process is difficult, owing to the typical uncertainties of biochemical process and the lack of suitable on-line sensors for primary process variables. A prediction model based on Gaussian Process Regression (GPR) is presented to predict glutamate concentration online. First, Partial Least Squares (PLS) is applied to extract the features of the input secondary variables to reduce the number of the variables dimension and eliminate the correlation, through variables selection to reduce model complexity and improve model tracking performance. Validation was carried out in a 5 L fermentation tank for 10 batches glutamate fermentation process. Simulation results show that the proposed model outperforms the PLS and Support Vector Machine (SVM) model and the Root Mean Square Error (RMSE) are 1.59, 7.98 and 1.95, respectively. It can provide effective operation guidance for control and optimization of the glutamate fermentation process.


© 2016 Rongjian Zheng and Feng Pan. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.