Mesenchymal Stem Cell Transplantation for Retinal Degenerations and Dystrophies: Present and Future
Emma Ghazaryan, Shurong Wang, Yan Zhang, Yuxi He and Guanfang Su
DOI : 10.3844/ajbbsp.2014.241.250
American Journal of Biochemistry and Biotechnology
Volume 10, Issue 4
Retinal degenerations are the main causes of irreversible blindness in developed countries. Up to date the main pathological mechanisms of these diseases are not fully understood and consequently there is no complete treatment option for those diseases. In this aspect stem cells have drawn attention of many researchers and health care professionals. Considering ethical issues, safety and facile isolation Mesenchymal Stem Cells (MSCs) are more preferable for practical use. They have been used for several preclinical and clinical trials. In general the results were promising, however broader practical use should be preceded by resolving many problems and questions. In this review we will describe mesenchymal stem cells, especially those derived from Bone-Marrow (BMSC), their main features, privilege, mechanisms of action and their potential use for the treatment of retinal degenerations. We will also discuss the results of several pre-clinical and clinical trials.
© 2014 Emma Ghazaryan, Shurong Wang, Yan Zhang, Yuxi He and Guanfang Su. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.