Anti β2-Glycoprotein I Antibodies in Women with Recurrent Spontaneous Abortion
Abdolreza Sotoodeh Jahromi, Mohammad Reza Farjam, Farideh Mogharrab, Ali Daryanavard and Abdolhossien Madani
DOI : 10.3844/ajbbsp.2010.264.267
American Journal of Biochemistry and Biotechnology
Volume 6, Issue 4
Problem statement: Antiphospholipid antibodies (aPL) are associated with repeated miscarriages and pregnancy complications, however their pathogenic mechanisms are still matter of research. Anti-β2 glycoprotein 1 (β2GPI) antibody is one of these aPL that its contribution to RSA risk remains poorly understood. There were not any data about role this auto-antibody in RSA in South of Iran. This study was conducted to assess Anti- β2GPI IgM and IgG as RSA risk factors for RSA in this area of Iran. Approach: This case-control study was carried out in gynecology special hospital of Hormozgan University of medical sciences, during 2004-2005. A number of 250 women with >3 consecutive idiopathic pregnancy losses as a case group and 200 age matched women with normal full term delivery and negative history of miscarriage as a controls were studied. All obtained sera from the case and the control groups were tested using an Enzyme Linked Immunosorbent Assay (ELISA) method for detection of anti-β2GPI IgM and IgG. Data was analyzed, using SAS 8 statistical software (chi square and t-test). Results: There were significant differences between the prevalence of positive anti-β2GPI IgM (p = 0.01) and IgG (p = 0.02) in the case group and the control group. A positive significant relationship was observed in the case group between number of abortion and seropositivity for anti-β2GPI IgG (p = 0.028, r = +0.181) and anti-β2GPI IgM (p = 0.0381, r = +0.014). Conclusion: This study showed anti-β2GPI antibodies are important causative agent for RSA in this area of Iran.
© 2010 Abdolreza Sotoodeh Jahromi, Mohammad Reza Farjam, Farideh Mogharrab, Ali Daryanavard and Abdolhossien Madani. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.