American Journal of Biochemistry and Biotechnology

The Role of Neurodevelopmental Genes in Infectious Etiology of Autism

S. Hossein Fatemi

DOI : 10.3844/ajbbsp.2008.177.182

American Journal of Biochemistry and Biotechnology

Volume 4, Issue 2

Pages 177-182


Autism is a neurodevelopmental disorder with both genetic and environmental etiologies. Prenatal infections may play a role in evolution of autism. Experimental evidence shows human influenza viral infection in pregnancy leads to significant deleterious effects in brain structure and function in the developing mouse progeny. Several brain genes of interest in this animal model are also involved in the pathology of autism. The roles of these genes in brain development are discussed in this review.


© 2008 S. Hossein Fatemi. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.