American Journal of Biochemistry and Biotechnology

Effect of Short Time Morphine Addiction on the Kidney Tissue in Rat

Reza Malekpourafshar and Hamid Zeinalinejad

DOI : 10.3844/ajbbsp.2005.186.188

American Journal of Biochemistry and Biotechnology

Volume 1, Issue 4

Pages 186-188


Opium is an important substance that abuses and has very pharmacological and pathological effects. Morphine is the main substance of opium. In the recent study, it has been tried to identify the short effects of morphine on the kidney pathology of Rats. The randomized double blind study was designed. Twenty rats were selected and divided in two groups and maintained under routine laboratory conditions and similar intervention. One group had been addicted orally by morphine powder and control were not addict. After three weeks, all rats were anesthetized and underwent autopsy. Their kidneys were removed en-block and sent to pathology laboratory and reviewed by one pathologist. The major considered variables were tubulo-interstitial and glomerular changes, glomerular amount and size on light microscope view. Glomerular, tubular and vascular changes, glomerular counts, glomerular size, and cortical thickness showed no significant differences between groups of study. Only Lymphocytic infiltration was higher frequency in addict group, significantly P=0.007. It seems short course of morphine consumption is very little effect on kidney, only Lymphocytic infiltration observe in addicted renal tissue which, may be precursor of other changes in kidney. It is better long term studies are implemented in this course.


© 2005 Reza Malekpourafshar and Hamid Zeinalinejad. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.