American Journal of Pharmacology and Toxicology


American Journal of Pharmacology and Toxicology is a peer-reviewed open access journal that publishes original research / review articles on drug action in all the areas of pharmacology and toxicology including in vivo and in vitro metabolism, intracellular metabolism and intracellular regulation. Articles on effects of radiations, drug composition and properties, drug-drug interactions, pharmacokinetic and in vivo imaging of drug distribution are also encouraged. AJPT is a quarterly publication available both in print and online and is an authentic source of information on Pharmacology and Toxicology.

Letter from the Editor in Chief

Pharmacology and toxicology have evolved to scientific disciplines from human activities almost 7000 years old. It has always been a human attempt to identify new therapeutics from natural product sources, while learning their limitation and side effects the hard way. They became recognized disciplines only at the beginning of the 19th century, with the increasing tendency to explore the action of drugs and natural extracts on tissue and organ functions, as well as their use as tools to understand the origin of diseases.

From those times, the exponential increase of understanding of receptor and targets, from organ to cellular to nuclear levels has driven the research in these fields. With the advent of molecular biology and the use of technology platforms, pharmacology and toxicology seemed to have lost their role of integrative disciplines. Most recently, the need to go back to “the big picture” has characterize a new attention waive to pharmacology and toxicology, with the creation of disciplines, such as quantitative and system pharmacology or translational pharmacology, which encase concepts that have always been the basis of “classical” pharmacology and toxicology.

In these new times, I am excited to join American Journal of Pharmacology and Toxicology (AJPT) as Editor in Chief. AJPT was launched as open access journal in March 2006 and meanwhile has become truly international, publishing original articles and reviews from all over the world including countries from Africa, Asia, Europe, and America.

My mission is to promote AJPT as a key title in the field, publishing papers of outstanding quality covering all the multifaceted aspects of pharmacology and toxicology, from target identification to pharmaco- and toxico-kinetics, from drug-drug interaction to non-clinical regulatory and human toxicology and, to keep faith to the origins of the discipline, to the actions of natural extracts. My hope is that AJPT will continue to grow and to provide excelling information to everybody in these fields.

I like to take this opportunity to invite scientists and clinicians from all over the world to submit their manuscripts to AJPT and to contribute in this way to spread the knowledge in pharmacology and toxicology.

  • Tiziana Adage
    Editor in Chief
    American Journal of Pharmacology and Toxicology

Current Issue

Neutrophil Extracellular Traps as Therapeutic Targets for Inflammatory Disease

Pages : 200-202

DOI : 10.3844/ajptsp.2014.200.202

Published On : February 25, 2015

Neutrophil Extracellular Traps as Therapeutic Targets for Inflammatory Disease

Rory R. Koenen
Volume : 9, Issue : 4 Pages : 200-202
Published On : February 25, 2015

Anti-Inflammatory, Analgesic and Antioxidant Activities of Allophylus Cobbe Leaves

Preeti Jain, Md. Selim Hossain, Kaniz Fatema, Md. Ali Akbar Hossain, Kafil Uddin Mazumder, Hemayet Hossain, Md. Ashraful Alam and Hasan Mahmud Reza
Volume : 9, Issue : 4 Pages : 223-231
Published On : January 27, 2015

Effect of Combined Fenofibrate and Nicotinamide on Oxidative Stress and Inflammatory Cytokines Involved in Cisplatin-Induced Nephrotoxicity in Rats

Omaima M. Abd Allah, Abeer A.I. Sharaf El-Din and Fouad El Debakey
Volume : 9, Issue : 4 Pages : 206-222
Published On : January 9, 2015


Karen Exley, Sarah Robertson, Francis D. Pope, Roy M. Harrison and Timothy W. Gant
Volume : 9, Issue : 3 Pages : 189-199
Published On : October 28, 2014


Ruchi Tiwari and Kuldeep Dhama
Volume : 9, Issue : 3 Pages : 174-176
Published On : September 26, 2014

Tamoxifen Drug Loading Solid Lipid Nanoparticles Prepared by Hot High Pressure Homogenization Techniques

Nagi A. ALHaj, Rasedee Abdullah, Siddig Ibrahim and Ahmad Bustamam
Volume : 3, Issue : 3 Pages : 219-224
Cites : 27

An Analysis of the Creatine Kinase Isoenzyme and Cardiac Troponin T Levels in a Polymyositis Patient

R. M. Golding, L. G.F. Giles and E. M. Sokoya
Volume : 4, Issue : 1 Pages : 1-7
Cites : 25

Cardioprotective Effect of Cucumis trigonus Roxb on Isoproterenol-Induced Myocardial Infarction in Rat

B. S. Thippeswamy, S. P. Thakker, S. Tubachi, G. A. Kalyani, M. K. Netra, U. Patil, S. Desai, C. C. Gavimath and V. P. Veerapur
Volume : 4, Issue : 2 Pages : 29-37
Cites : 21

Volume : 3, Issue : 1 Pages : 69-76
Cites : 21

Anti-Ulcer (Ulcer-Preventive) Activity of Ficus arnottiana Miq. (Moraceae) Leaf Methanolic Extract

Marslin Gregory, K. P. Vithalrao, G. Franklin and V. Kalaichelavan
Volume : 4, Issue : 3 Pages : 89-93
Cites : 20

Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

Atef M. Al-Attar
Volume : 5, Issue : 1 Pages : 14-23
Downloads : 26191


Suryakant K. Niture and Lubna Refai
Volume : 8, Issue : 1 Pages : 9-19
Downloads : 11370

Acute and Sub-acute Toxicity of Crataegus Aronia Syn. Azarolus (L.) Whole Plant Aqueous Extract in Wistar Rats

Abdullah S. Shatoor
Volume : 6, Issue : 2 Pages : 37-45
Downloads : 5760

In Vitro and In Vivo Anticancer Activity of Bacoside A from Whole Plant of Bacopa Monnieiri (Linn)

N. S. Prakash, R. Sundaram and S. K. Mitra
Volume : 6, Issue : 1 Pages : 11-19
Downloads : 4128

Bilirubin Lowering Potential of Annona muricata (Linn.) In Temporary Jaundiced Rats

Fareed K.N. Arthur, Eric Woode, Ebenezer O. Terlabi and Christopher Larbie
Volume : 7, Issue : 2 Pages : 33-40
Downloads : 2944

Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

Atef M. Al-Attar
Volume : 5, Issue : 1 Pages : 14-23
Views : 30189

Characterization of Nigella Sativa L. Essential Oil-Loaded Solid Lipid Nanoparticles

Nagi A. ALHaj, Mariana N. Shamsudin, Norfarrah M. Alipiah, Hana F. Zamri, Ahmad Bustamam, Siddig Ibrahim and Rasedee Abdullah
Volume : 5, Issue : 1 Pages : 52-57
Views : 1309

Uncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel Mechanism

Claudia Maturo, King C. Lee, Robert Rodriguez and Robert Shorr
Volume : 5, Issue : 4 Pages : 183-208
Views : 1217

Hepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino Rats

Ajay k. Gupta and Neelam Misra
Volume : 1, Issue : 1 Pages : 17-20
Views : 1197

Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats

T. S. Muralidhar, Anna Balaji, Chinmay Bandopadhyay and S. L. Shantha
Volume : 4, Issue : 3 Pages : 80-84
Views : 984