Research Article Open Access

Hepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino Rats

Ajay k. Gupta1 and Neelam Misra1
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American Journal of Pharmacology and Toxicology
Volume 1 No. 1, 2006, 17-20

DOI: https://doi.org/10.3844/ajptsp.2006.17.20

Submitted On: 23 October 2006 Published On: 31 March 2006

How to Cite: Gupta, A. K. & Misra, N. (2006). Hepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino Rats . American Journal of Pharmacology and Toxicology, 1(1), 17-20. https://doi.org/10.3844/ajptsp.2006.17.20

Abstract

Hepatoprotective activity of aqueous ethanolic extract of Chamomile recutita capitula against paracetamol induced hepatic damage in albino rats was observed. In the present study the effect of aqueous ethanolic extract of Chamomile recutita capitula on blood and liver glutathione, Na+ K+- ATPase activity, serum marker enzymes, serum bilirubin, glycogen and thiobarbutiric acid reactive substances against paracetamol induced damage in rats have been studied to find out the possible mechanism of hepatoprotection. It was observed that extract of chamomile has reversal effects on the levels of above-mentioned parameters in paracetamol hepatotoxicity. The extract of capitula of chamomile functions as a hepatoprotective agent and this hepatoprotective activity of chamomile may be due normalization of impaired membrane function activity.

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Keywords

  • Chamomile recutita
  • glutathione
  • hepatoprotection
  • lipid peroxidation
  • Na+K+-ATPase
  • paracetamol
  • thiobarbutiric acid reactive substances
  • serum marker enzymes