Research Article Open Access

Effect of Verapamil on Serum Level of Salinomycin in Diabetic Rats

Hossein Najafzadeh1, Said Reza Fatemi2 and Amir Ashna1
  • 1 ,
  • 2 , Afganistan
American Journal of Applied Sciences
Volume 8 No. 9, 2011, 860-863

DOI: https://doi.org/10.3844/ajassp.2011.860.863

Submitted On: 13 May 2011 Published On: 1 August 2011

How to Cite: Najafzadeh, H., Fatemi, S. R. & Ashna, A. (2011). Effect of Verapamil on Serum Level of Salinomycin in Diabetic Rats. American Journal of Applied Sciences, 8(9), 860-863. https://doi.org/10.3844/ajassp.2011.860.863

Abstract

Problem statement: The aim of present study was evaluation function of P-glycoprotein with or without verapamil in normal and diabetic rats; which the function of P-glycoprotein was indirectly evaluated by detection of serum slainomycin concentration with HPLC method. Approach: This study was carried in 4 groups of rats including normal rats which received salinomycin and verapamil together salinomycin; and diabetic rats which received salinomycin and verapamil together salinomycin. Serum concentration of salinomycin was measured by HPLC after 3 h from its administration. Results: Results show the serum concentration of salinomycin significantly elevated in diabetic rats which received verapamil together salinomycin; while this concentration did not significantly change in other groups. Conclusion: Since the p-glycoprotein activity decreases in diabetic conditions and verapamil inhibits it; probably transport of salinomycin from blood to tissues or its elimination was decreased that caused its elevated serum concentration.

  • 1,185 Views
  • 2,086 Downloads
  • 0 Citations

Download

Keywords

  • Salinomycin significantly
  • verapamil inhibits
  • diabetes induction
  • HPLC method
  • serum concentration
  • p-glycoprotein
  • diabetic rats
  • serum level
  • tumor cells