TY  - JOUR
AU  - Najafzadeh, Hossein 
AU  - Fatemi, Said Reza 
AU  - Ashna, Amir 
PY  - 2011
TI  - Effect of Verapamil on Serum Level of Salinomycin in Diabetic Rats
JF  - American Journal of Applied Sciences
VL  - 8
IS  - 9
DO  - 10.3844/ajassp.2011.860.863
UR  - https://thescipub.com/abstract/ajassp.2011.860.863
AB  - Problem statement: The aim of present study was evaluation function of P-glycoprotein with or without verapamil in normal and diabetic rats; which the function of P-glycoprotein was indirectly evaluated by detection of serum slainomycin concentration with HPLC method. Approach: This study was carried in 4 groups of rats including normal rats which received salinomycin and verapamil together salinomycin; and diabetic rats which received salinomycin and verapamil together salinomycin. Serum concentration of salinomycin was measured by HPLC after 3 h from its administration. Results: Results show the serum concentration of salinomycin significantly elevated in diabetic rats which received verapamil together salinomycin; while this concentration did not significantly change in other groups. Conclusion: Since the p-glycoprotein activity decreases in diabetic conditions and verapamil inhibits it; probably transport of salinomycin from blood to tissues or its elimination was decreased that caused its elevated serum concentration.