@article {10.3844/ajassp.2011.860.863,
article_type = {journal},
title = {Effect of Verapamil on Serum Level of Salinomycin in Diabetic Rats},
author = {Najafzadeh, Hossein and Fatemi, Said Reza and Ashna, Amir},
volume = {8},
year = {2011},
month = {Aug},
pages = {860-863},
doi = {10.3844/ajassp.2011.860.863},
url = {https://thescipub.com/abstract/ajassp.2011.860.863},
abstract = {Problem statement: The aim of present study was evaluation function of P-glycoprotein with or without verapamil in normal and diabetic rats; which the function of P-glycoprotein was indirectly evaluated by detection of serum slainomycin concentration with HPLC method. Approach: This study was carried in 4 groups of rats including normal rats which received salinomycin and verapamil together salinomycin; and diabetic rats which received salinomycin and verapamil together salinomycin. Serum concentration of salinomycin was measured by HPLC after 3 h from its administration. Results: Results show the serum concentration of salinomycin significantly elevated in diabetic rats which received verapamil together salinomycin; while this concentration did not significantly change in other groups. Conclusion: Since the p-glycoprotein activity decreases in diabetic conditions and verapamil inhibits it; probably transport of salinomycin from blood to tissues or its elimination was decreased that caused its elevated serum concentration.},
journal = {American Journal of Applied Sciences},
publisher = {Science Publications}
}