OnLine Journal of Biological Sciences

Studying Interrelation of PDLIM4 with the Model of CD74-Mediated Development of Breast Cancer

Dmitry Sergeevich Kravchenko, Yuriy Nikolaevich Lezhnin, Anna Evgenyevna Ivanova, Yulia Evgenyevna Kravchenko and Elena Ivanovna Frolova

DOI : 10.3844/ojbsci.2017.50.57

OnLine Journal of Biological Sciences

Volume 17, Issue 2

Pages 50-57

Abstract

Mammary gland tumors are often characterized by deregulation of RIL/PDLIM4 expression, however, PDLIM4-mediated mechanisms of cancer development still remain unknown. The aim of our research was to study the influence of PDLIM4-deregulation on transcript me changes of malignized cells. We performed ? comparative NGS-analysis of breast cancer cell lines with suppressed and induced expression of PDLIM4 and identified a number of genes, whose expression correlated with PDLIM4 level. Among them we found CD74 gene, which is known as a potential marker of triple negative subtype of breast cancer. The obtained results allowed us to propose an interrelation between PDLIM4 and the CD74-mediated mechanism of breast cancer development and to analyze the correlation of PDLIM4 with the main components of CD-74-dependent model.

Copyright

© 2017 Dmitry Sergeevich Kravchenko, Yuriy Nikolaevich Lezhnin, Anna Evgenyevna Ivanova, Yulia Evgenyevna Kravchenko and Elena Ivanovna Frolova. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.