@article {10.3844/ojbsci.2017.50.57,
article_type = {journal},
title = {Studying Interrelation of PDLIM4 with the Model of CD74-Mediated Development of Breast Cancer},
author = {Kravchenko, Dmitry Sergeevich and Lezhnin, Yuriy Nikolaevich and Ivanova, Anna Evgenyevna and Kravchenko, Yulia Evgenyevna and Frolova, Elena Ivanovna},
volume = {17},
number = {2},
year = {2017},
month = {Jun},
pages = {50-57},
doi = {10.3844/ojbsci.2017.50.57},
url = {https://thescipub.com/abstract/ojbsci.2017.50.57},
abstract = {Mammary gland tumors are often characterized by deregulation of RIL/PDLIM4 expression, however, PDLIM4-mediated mechanisms of cancer development still remain unknown. The aim of our research was to study the influence of PDLIM4-deregulation on transcript me changes of malignized cells. We performed а comparative NGS-analysis of breast cancer cell lines with suppressed and induced expression of PDLIM4 and identified a number of genes, whose expression correlated with PDLIM4 level. Among them we found CD74 gene, which is known as a potential marker of triple negative subtype of breast cancer. The obtained results allowed us to propose an interrelation between PDLIM4 and the CD74-mediated mechanism of breast cancer development and to analyze the correlation of PDLIM4 with the main components of CD-74-dependent model.},
journal = {OnLine Journal of Biological Sciences},
publisher = {Science Publications}
}