TY  - JOUR
AU  - Kravchenko, Dmitry Sergeevich 
AU  - Lezhnin, Yuriy Nikolaevich 
AU  - Ivanova, Anna Evgenyevna 
AU  - Kravchenko, Yulia Evgenyevna 
AU  - Frolova, Elena Ivanovna 
PY  - 2017
TI  - Studying Interrelation of PDLIM4 with the Model of CD74-Mediated Development of Breast Cancer
JF  - OnLine Journal of Biological Sciences
VL  - 17
IS  - 2
DO  - 10.3844/ojbsci.2017.50.57
UR  - https://thescipub.com/abstract/ojbsci.2017.50.57
AB  - Mammary gland tumors are often characterized by deregulation of RIL/PDLIM4 expression, however, PDLIM4-mediated mechanisms of cancer development still remain unknown. The aim of our research was to study the influence of PDLIM4-deregulation on transcript me changes of malignized cells. We performed а comparative NGS-analysis of breast cancer cell lines with suppressed and induced expression of PDLIM4 and identified a number of genes, whose expression correlated with PDLIM4 level. Among them we found CD74 gene, which is known as a potential marker of triple negative subtype of breast cancer. The obtained results allowed us to propose an interrelation between PDLIM4 and the CD74-mediated mechanism of breast cancer development and to analyze the correlation of PDLIM4 with the main components of CD-74-dependent model.