American Journal of Biochemistry and Biotechnology

Review of the Progress in Corneal Neovascularization Animal Models

Shuci Tian, Shurong Wang, Yuxi He, Xin Liu, Ying Li, Guanfang Su and Yan Zhang

DOI : 10.3844/ajbbsp.2015.221.227

American Journal of Biochemistry and Biotechnology

Volume 11, Issue 4

Pages 221-227

Abstract

Corneal Neovascularization (CNV), the extensive growth of blood vessels from conjunctiva into the cornea. It is a sight-threatening condition that can decreases eyesight and even leads to blindness. The pathologic growth of blood vessels impairs light transmission, promotes scar formation and causes inflammations, which harm visual acuity. Abnormal angiogenesis plays an important role in the process of CNV, which may result from corneal wound healing. Neovascular eye disease is one of the most common eye diseases in clinical admissions. CNV blinds approximately 7 million people worldwide. Continued mechanistic studies are a key to the prevention and treatment of CNV. Research in CNV animal models is essential in eye diseases. Several main methods of CNV models preparation are summarized in this review.

Copyright

© 2015 Shuci Tian, Shurong Wang, Yuxi He, Xin Liu, Ying Li, Guanfang Su and Yan Zhang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.