TY  - JOUR
AU  - Tian, Shuci 
AU  - Wang, Shurong 
AU  - He, Yuxi 
AU  - Liu, Xin 
AU  - Li, Ying 
AU  - Su, Guanfang 
AU  - Zhang, Yan 
PY  - 2015
TI  - Review of the Progress in Corneal Neovascularization Animal Models
JF  - American Journal of Biochemistry and Biotechnology
VL  - 11
IS  - 4
DO  - 10.3844/ajbbsp.2015.221.227
UR  - https://thescipub.com/abstract/ajbbsp.2015.221.227
AB  - Corneal Neovascularization (CNV), the extensive growth of blood vessels from conjunctiva into the cornea. It is a sight-threatening condition that can decreases eyesight and even leads to blindness. The pathologic growth of blood vessels impairs light transmission, promotes scar formation and causes inflammations, which harm visual acuity. Abnormal angiogenesis plays an important role in the process of CNV, which may result from corneal wound healing. Neovascular eye disease is one of the most common eye diseases in clinical admissions. CNV blinds approximately 7 million people worldwide. Continued mechanistic studies are a key to the prevention and treatment of CNV. Research in CNV animal models is essential in eye diseases. Several main methods of CNV models preparation are summarized in this review.