Omicron SARS Co-V2 Sub Variants BA.2 and BA.3 have Lower Free Binding Energy than BA.1

Abstract

COVID-19 is currently a major global public health concern. The newest dangerous type, Omicron, comes in late 2021 and spreads quickly from Africa. There have already been new omicron subvariants discovered. Mutations inside the molecular structure of omicron subvariant induce intriguing molecular changes. The authors undertook a study to examine the effects of mutations in important COVID-19 omicron subvariants, including BA.1, BA.2, and BA.3, based on free binding energy alterations. According to molecular study findings, each studied subvariant has a different free binding energy. The BA.3 has undergone the most changes. As a result, the binding of ACE-2 may be affected. This suggests that the new subvariant may be linked to a higher likelihood of transmission.