Research Article Open Access

Anticancer Activity of Some New Synthesized Tetrahydroquinoline and Tetrahydrochromene Carbonitrile Derivatives

Usama W. Hawas1, Mohamed A. Al-Omar2, Abd El-Galil E. Amr3 and Abu El-Ftouh G. Hammam1
  • 1 Department Applied Organic Chemistry, National Research Center, Dokki, Cairo, Egypt
  • 2 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
  • 3 Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

Abstract

Problem statement: In continuation to our search for new heterocyclic chemistry based anticancer, the suggestion, synthesis, structure elucidation of some naphthalene, chromene and quinoline derivatives 3-7 were realized herein using 3-methylcyclohexanone 1 as a starting material. Approach: The antitumor activities of the newly synthesized compounds 4-7 were evaluated utilizing 60 different human tumor cell lines, representing leukemia, melanoma, lung, colon, brain, ovary, breast and prostate as well as kidney. Results: Some of the tested compounds exhibited better in vitro antitumor activities at low concentration (log10 GI50 = -4.7) against the used human tumor cell lines. Conclusion: From the obtained results, we can conclude that cyanopyridine and pyrane moieties fused to 3-methycyclohexane ring are essential for antitumor activities. In the present work, we can suggest that the anticancer activity is due to the presence of nitrogen heterocyclic rings and the presence of the nitrile groups (CN) generally enhancing the activity.

American Journal of Applied Sciences
Volume 8 No. 10, 2011, 945-952

DOI: https://doi.org/10.3844/ajassp.2011.945.952

Submitted On: 23 August 2010 Published On: 14 September 2011

How to Cite: Hawas, U. W., Al-Omar, M. A., Amr, A. E. E. & Hammam, A. E. G. (2011). Anticancer Activity of Some New Synthesized Tetrahydroquinoline and Tetrahydrochromene Carbonitrile Derivatives. American Journal of Applied Sciences, 8(10), 945-952. https://doi.org/10.3844/ajassp.2011.945.952

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Keywords

  • Synthesis
  • REACTIONS
  • 2,6-Bis-(3,4-dimethoxybenzylidene)-3-methylcyclo-hexanone
  • tetrahydroquinoline
  • tetrahydrochromene
  • pyranes
  • cyanopyridine
  • anticancer activity